Fact vs. Fiction: The Science of ‘Limitless’

Maybe it’s Bradley Cooper’s particular brand of smirky hunkiness or the draw of DeNiro, but Limitless wound up the #1 movie in theaters this past weekend. We’re guessing the real reason the power fantasy beat out the other new releases is because just about everyone harbors the desire to be smarter, to be more than what you are.

In the movie, Cooper plays Eddie Mora, an author with an epic case of writer’s block who comes across a less-than-legal drug called NZT. The shady substance unlocks Mora’s untapped neural potential, letting him finished that stalled novel and make a killing on the stock market. As out there as the premise of Limitless is, there is some basis in reality for the movie’s plot. Scan the web and you’ll find stories of wannabe writers taking drugs like Adderall to help them concentrate, while other creative types swear by the shot glass or caffeine rush to channel their creativity.

So, what are the stakes when you decide to chemically alter your grey matter to “unlock” some extra smarts? The persistent myth is that people only use 10% of the brain’s potential, but clinical and research psychologist Paula Caplan says “We have no idea how much of the brain is actually used.” Moreover, she adds, “Most people have the impression that if a brain researcher claims they found something, then the finding must be true, when the fact is, at this stage of research on the brain, there is no way to quantify the use of the brain in terms of percentage.” Caplan talked a bit more to Techland about about where real-life science matches up with Limitless.

It’s not like recreational drugs, where people get high for pleasure, so why do people pursue psychopharmaceutical enhancement?

People actually can get high from certain prescription drugs that are sold to treat psychopathologies, if they take the right amounts. So this mood-altering effect could cause people to want more, as Bradley Cooper does in the film. In general, people seek prescription psychoactive drugs because they feel or function badly and want to feel or function better. These people believe what the experts tell them, or in the case of Bradley Cooper’s character in Limitless, believe the pill pusher and feel that a pill will be an easy fix to a pressing problem. In the United States, the average worker works much more than they did even 10 years ago. Many people feel they don’t have time for psychotherapy or other activities that could help, so the idea of simply taking a pill in order to get rid of their problems becomes very attractive. However, in real life as in Limitless, taking a pill as a quick fix may have far-reaching negative consequences.

What real-life drugs come closest to the fictional drug NZT? What are the kinds of results do people see with these pills?

Drugs similar to the fictional drug NZT in a couple of ways would be any stimulant medication. These kinds of drugs move a person toward increased ability to concentrate and away from distractibility. The better one can focus, the more information one can take in. Concentration and distractibility exist on opposite ends of a continuum, and the person taking a stimulant will be affected based upon their position on that continuum. In this, a stimulant will affect someone much differently if they are mentally closer to the distraction side of the continuum vs. someone who is closer to the focusing end. One problem with such drugs, as illustrated inLimitless, is that when they wear off, there can be a rebound effect, in which the problem being treated gets worse than ever, and doctors and patients mistakenly conclude that the patients need even more drugs.

Eddie Mora beats up some assailants after remembering some kung-fu movies he’d watched. Would an increase in brain function necessarily correlate to an increase in physical prowess? What would be the actual bodily repercussions of such enhancement?

For the most part, no. If someone wants to be a better golfer, watching an expert golfer carefully might help give this observer the edge over a fellow novice who did not watch the expert, but to be proficient at a high level, the person must have physical practice. A person on NZT, like Eddie Mora in Limitless, might need less physical practice because he has a perfect memory of the activity he is recalling, but it would be difficult to translate perfect memory in to physical strength or agility. The physical repercussions of a novice forcing their body to do things they have watched an expert do would probably be the same aches and pains as would any of us have, whether they are on a drug with the effects that NZT supposedly has or not. And if NZT acted like stimulant drugs, the pain would be experienced more intensely, because all of their concentration will be on the pain.

Bradley Cooper’s motivation for taking NZT is to get over writer’s block. What part of the brain handles that kind of creativity and what would you need to do, chemically, to jumpstart it?

No one really knows the part of the brain responsible for writing creatively. I know people who were put on stimulant medication to help them concentrate, but they found that they became less creative. This may be because the person needed a kind of distractible mind to allow it to jump rapidly from one thing to another, which inspired a diversity of thought and creativity, a kind of creativity that focusing more narrowly could have eliminated. For other people, focusing more is essential to their particular approach to writing, which could involve thinking through carefully a variety of directions in which the writing might or might not go. Writer’s block might occur because of shame, anxiety, or fearfulness. In Limitless, it was because Eddie Mora needed to be motivated. In Eddie’s case, the imaginary drug NZT appeared to have allowed him to maintain a diversity of concepts, yet at the same time focus on all concepts simultaneously, drawing out of them amazing content and story. In order to jumpstart the creative process without chemicals of any kind, one might want to do relaxing activities, like walking, or swimming. Having a stiff drink might even help but, of course, that is another kind of chemical.

What are some non-chemical things people can do to make their brain function more efficiently?

A lot of good research has shown that exercise positively affects mental health. There are also certain foods one should eat and certain foods one should avoid in order to maximize one’s cognitive functioning. Low levels of certain B vitamins can cause negative moods in some people, for example, and foods which cause sudden highs and lows of blood sugar might have difficulty thinking clearly. Participating in pro-social activities is shown to affect positively some cognitive functions and mood. Memory exercises can improve memory. It has been shown that elderly people who walk regularly have generally better memories than elderly people who do not. Many times, I’ve seen actors doing crossword puzzles just before they come on stage. In their case, concentration via crossword puzzles sharpens their mind and seems to help them focus intensively once they get onstage.


Related Topics: Bradley Cooper, brain science, fact vs. fiction, Limitless, mental superpowers, movies, Paula Caplan, Gaming & Culture
  • RichardSRussell

    Even the Bible noticed that it’s way more difficult for human women to give birth than it is for, say, horses or cows (tho, as usual, the superstitious “explanation” for why this was so — original sin — is just ludicrous). In fact, the evolutionary advantage of a big brain is so great that we’ve pushed it to the limit, with the giant skulls of our neonates almost rendering their mothers asunder, and our 1st 5-10 years of life devoted to growing our brains even bigger. It’s just silly, therefore, to assert that we’re paying such a fearsome price in exchange for using only 10% of our mental capacity. If that were really true, there would be immense evolutionary pressure to dial back to JUST that 10%.

  • http://techland.com/ Evan Narcisse

    Great comment, Richard. I just had a kid recently and the line of thinking you state has been going through my brain for weeks now. Three, four months without being able hold your head upright is a huge price to pay for that big ol’ brain and it seems that the young of other species aren’t quite as vulnerable in the same way as newborn humans are. Still, being the nerd that I am, I want the kid to have as big a brain as is feasible and use as much of it as baby can.

  • http://glakia.wordpress.com Lakia Gordon

    I really liked the movie (I saw it 2xs lol). It was a very interesting fact that we only used 20% of our brains. Thanks for sharing.

  • http://tinkerbelle86.wordpress.com tinkerbelle86

    this looks really good. obviously bradley cooper helps :)

  • http://mikeealy.wordpress.com mikeealy

    I really want to see this. should I see this in theaters or download it….I mean, wait til it comes out on DVD?….

  • http://writerdood.wordpress.com/ writerdood

    Nice analysis of the technology involved. I was going to wait for this one to come out on DVD, but now maybe I’ll see it in the theaters. I’m not sure. It’s interesting that the myth of humans only using 10% of their brains still pervades. Here’s an article on that from 2008: http://www.scientificamerican.com/article.cfm?id=people-only-use-10-percent-of-brain I think this concept has been known as false for decades, but somehow it still makes it into science fiction. But what the heck, it’s not really hurting anything.

  • http://claudiahaskin.wordpress.com chaskin23

    I think the movie is amazing in theory, but in reality it was extremely lame. It has the audience’s attention maybe 1/4 into the movie, but it technically has no argument. What is he trying to achieve exactly? Then it turns creepy when he decides to suck the blood off the floor because it contains the last of the drug… Frankly, staring at Bradley Cooper’s eyes for 100 minutes is not my idea of fun. I can’t believe DeNiro agreed to participate in the movie. Yes, it would be amazing to use all of our brain and remember useful information you were exposed to at some point…but do you seriously think your mind/body won’t pay the consequences? Just saying! ;-)

  • http://madisonhollandfoundationdotcom.wordpress.com Rena

    I must admit, I like to look and feel smart. I like knowing things that others may not. I love when my creative juices get flowing and there’s no stopping me. I pull over in my car to write, I get up in the middle of the night to write. I pause during sex to jot something down….just kidding. But If this drug were real and available, I’d take it. Because I want to reach my fullest potential at all times. Not just when I remember to eat right and exercise.

  • http://herenownotforever.wordpress.com eva626

    great stuff!!! cooper is very — !!! ahh lol

  • http://kimeling.wordpress.com Kim

    Bradley Cooper really helps a lot :D
    NOt too sure if I have enough time for that

  • seismedia

    Adderall = Amphetamine Salts = Speed.

    Discovered/developed in the early part of the 20th Century, primarily with the purpose of keeping soldiers in the trenches awake and alert. Refined by the Nazi’s, Japanese, and Allies during World War II.

    Combined with Methadrine, makes “Crystal Meth”.

    Amphetamine is a nor-epinephrine uptake inhibitor which helps one stay alert and for those with certain deficiencies, it balances them. Those without the defect, however, get a rush-high and are very susceptible to addiction. Many “twichy” side effects accompany it’s use because it stimulates the central nervous system such that external stimulus, particularly on appendages, skin, etc.. Also raises the heart rate significantly.

    All in all, not something one should experiment with:

    http://ecofren8888.blogspot.com/2011/01/drug-use-is-self-abuse.html

  • http://projectnationalist.wordpress.com Project-Nationalist

    I’ve been wanting to see this movie.

    As for the brain percentage usage, I thought scientist had a vague estimate for it. Of course I don’t think there is any way we could know an exact percentage now, in fact, I recall reading something about how it can vary from person to person (not sure how much difference it would make between different people though).

    That’s kinda beside the point, I’m pretty sure it’s documented that there is still a good percentage of our brain that is not in use, I’d like to think we would still benefit from such a pill- although I don’t believe current pills like Adderall or other things like that will actually help writers… Just to throw in my two cents in.

  • http://teamgojanitorial.wordpress.com teamgo

    i enjoyed reading this

  • http://johnlmalone.wordpress.com johnlmalone

    top article. a film I must see. good to see Bradley Cooper in a serious role after ‘The Hangover’ and as a writer I am fascinated by writers block. your article deals succintly with the issue

  • http://mycameramyfriend.wordpress.com My Camera, My Friend

    Great article. I’ve seen trailers for the movie and find the concept fascinating. As for creative brainpower, why should you risk hurting your brain in a quest to enhance it momentarily? Caffiene is only for when I need it to stay awake. Sometimes I go work outside, try another less serious creative exercise (for example, doodling or making little cartoon people online instead of photography), or clean house.

  • http://kurtivanyu.wordpress.com kurtivanyu

    Would definitely watch this. Very interesting. :D
    nice breakdown of points Evan

  • busyman1918

    interesting post and this was one movie I really wanted to see this weekend and well I am not surprised that it ended up number one in the box office however you bring up good facts I mean how do we measure how much of the brain we are using? what do we have to base these things on anyways enjoyed the good read congrats on being freshly pressed as well

  • http://realanonymousgirl.wordpress.com realanonymousgirl2011

    I’m interested in seeing this. It helps that Cooper is hot!

  • http://snoekbrown.wordpress.com Samuel Snoek-Brown

    I wish I could remember a few of the sources for this (there are many), but I’ve read a lot about caffeine stimulating the creative centers in the brain. (This is one reason that mass education found its genesis in Ottoman and, later, European coffeehouses.) Anecdotally, I know I write better — and, yes, faster — while drinking coffee. Yet Paula Caplan says we don’t know where those creative centers are, which would seem to suggest that all this other research I’d seen is flawed: how can we know that caffeine stimulates creative centers in the brain if we don’t know where those creative centers are? I’d be quite curious to hear more of Caplan’s thoughts on that.

    Thanks for this post! I had dismissed the film as silly, and I still do, but I really enjoyed this intelligent discussion of its implications!

  • http://mjwrightnz.wordpress.com Matthew Wright

    Hollywood has always gone for the barely-credible-science spectacular. The real way to enhance intellect is not through chemicals but through discovering your own potential. By learning HOW to think. What ‘defines’ intelligence? To me it’s a practised skill like anything else – and I certainly find it helps writers’ block. Think about it (as it were).

    Matthew Wright
    http://www.matthewwright.net
    http://mjwrightnz.wordpress.com

  • http://newauthoronamazon.wordpress.com newauthoronamazon

    Gosh I must be the only dumb person on the block…I had not a clue about taking drugs to help write. A pretty dumb way if you ask me…asking God to help you out is far far simpler…I should know…I did do that and he gave me the gift of my book MasterMind. But for that one needs to pray and maybe its not so cool for cool people to wanna do that. To each his own I guess. Hasta la vista.

  • http://mixxieboomboom.wordpress.com fey’s diary

    Someone recommended me this movie and I’m downloading it right now.

  • http://patrickbetdavid.wordpress.com PHP Agency

    There may not be a magic pill around to achieve “limitless potential”, but I think there might be a formula if you read about these “limitless” achievers and what they had in common.

    http://bit.ly/fLl2py

  • http://godzai.wordpress.com godzai

    There is a drug called Piracetam, and the later updates Anaracetam, and Oxyracetam, that enhance communication in the hypothalamus. I don’t know about using all brain potential or anything, but it definitely does something. Synchs left and right hemisphere signals? I’m not sure. It is non-toxic, and used I think primarily for Alzheimer patients.
    I don’t think it would help with investing in the stock market, like in the film. Anything that makes you have an eidetic memory will make you weird, not suave.

    I disagree with the notion that ADD targeted speed pills like ritalin(and friends) would work. Faster is not smarter. Look at meth heads. Sure, they may suddenly understand the inner workings of their V-8, and devise a duct tape/crazy glue pulley system to get it out of the car, but it never gets fully fixed and/or reassembled.

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